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Accelerate a Slow-Opening Massive Excel File
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ACCELERATE A SLOW-OPENING MASSIVE EXCEL FILE

There is no compacting function in Excel 2003 or its earlier versions. But Excel 2007, with the new .xlsx file extension, uses file compression, which shrinks spreadsheet files up to 75% of their girth in the earlier .xls format. Of course, that does you no good if you’re not planning to upgrade to Vista.
However, you can buy third-party programs that help. They don’t actually compress, but they do effectively shrink Excel files by eliminating empty cells and unnecessary data. One freeware program, which is available at www.appspro.com/Utilities/Utilities.htm, is especially good at cleaning macro code, which becomes bloated by multiple edits. Several programs claim compacting abilities, and you may want to take advantage of free trial offers. You can locate them by googling Excel file compacting.
Another step you can take is to reset the file’s data range— the area that Excel interprets as containing data, which mistakenly also includes cells that have been cleared of data. To do that, open your workbook and press Ctrl+End. If you’re taken way beyond your data, that indicates Excel considers even those apparently blank cells as part of the workbook’s data range, and those apparently empty cells artificially inflate the file.